Zantac 75 and Excedrin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Zantac 75 (ranitidine hydrochloride) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.
The phase IV clinical study analyzes what interactions people have when they take Zantac 75 and Excedrin. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.
What is Zantac 75?
Zantac 75 has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,796 Zantac 75 users. Check the latest studies of Zantac 75.
What is Excedrin?
Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.
18 people who take Zantac 75 and Excedrin together, and have interactions are studied.

What are the common drug interactions of Zantac 75 and Excedrin, by gender? *:
female:
- Chronic kidney disease
- Renal failure (kidney dysfunction)
- Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
male:
- Chronic kidney disease
- Renal failure (kidney dysfunction)
What are the common drug interactions of Zantac 75 and Excedrin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Chronic kidney disease
50-59:
n/a
60+:
- Chronic kidney disease
- Renal failure (kidney dysfunction)
- Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
What are the existing conditions these people have? *
- Nausea (feeling of having an urge to vomit): 10 people, 55.56%
- Indigestion: 10 people, 55.56%
- Inflammation: 10 people, 55.56%
- Ammonia Abnormal: 7 people, 38.89%
- Hepatitis C: 7 people, 38.89%
- Herpes Virus Infection: 7 people, 38.89%
- Fatigue (feeling of tiredness): 7 people, 38.89%
- High Blood Pressure: 6 people, 33.33%
- Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 33.33%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 33.33%
* Approximation only. Some reports may have incomplete information.
Do you take Zantac 75 and Excedrin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Zantac 75 and Excedrin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Zantac 75:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Excedrin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zantac 75 and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Excedrin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on ranitidine hydrochloride and acetaminophen; aspirin; caffeine (the active ingredients of Zantac 75 and Excedrin, respectively), and Zantac 75 and Excedrin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Could Tysabri cause Proctitis? - a second ago
- Could Condylox cause Joint Swelling? - 7 seconds ago
- Nuclear Magnetic Resonance Imaging Thoracic Abnormal and Itching - 8 seconds ago
- Hypoglycaemia Aggravated and Appetite Decreased - 17 seconds ago
- Hypoglycaemia Aggravated and Appetite - Decreased - 17 seconds ago
- Could Enalapril Maleate cause Hyperlipidaemia? - 19 seconds ago
- Could Folic Acid cause Cough? - 20 seconds ago
- Could Miralax cause Paradoxical Drug Reaction? - 21 seconds ago
- Could Combivir cause Mental Status Changes? - 21 seconds ago
- Could Ofirmev cause Weakness? - 21 seconds ago