Zantac and Celestone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zantac (ranitidine hydrochloride) and Celestone (betamethasone). Common drug interactions include eye swelling among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zantac and Celestone. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

What is Celestone?

Celestone has active ingredients of betamethasone. It is often used in bursitis. eHealthMe is studying from 1,788 Celestone users. Check the latest studies of Celestone.

On Jul, 14, 2026

38 people who take Zantac and Celestone together, and have interactions are studied.

What are the common drug interactions of Zantac and Celestone, by gender? *:

female:

Eye swelling
Photophobia (extreme sensitivity to light)
Pupillary reflex impaired
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Abdominal pain upper
Aggression
Anxiety
Aseptic necrosis bone
Atelectasis neonatal (partial or complete collapse of the lung in newborn)

male:

Chronic kidney disease
Attention deficit/hyperactivity disorder
Diarrhoea
Drug eruption (adverse drug reaction of the skin)
Enuresis (repeated inability to control urination)
Eosinophil count increased
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Haematoma (collection of blood outside the blood vessels)
Lymphocyte stimulation test positive
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Zantac and Celestone, by age (0-1 to 60+)? *:

0-1:

Attention deficit/hyperactivity disorder
Autism spectrum disorder (developmental disabilities that can cause significant social, communication and behavioural challenges)
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)
Cardiomegaly (increased size of heart than normal)
Developmental delay
Enuresis (repeated inability to control urination)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Pericardial effusion (fluid around the heart)
Respiratory disorder neonatal (disease of respiratory organs in a month old baby)

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anger
Drug dependence
Sedation
Anxiety
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Concussion (short loss of normal brain function in response to a head injury)
Dyspnoea (difficult or laboured respiration)
Exacerbation of anxiety (increase in the severity of anxiety)
Herpes simplex (herpes simplex is a common viral infection)

40-49:

Hypertensive nephropathy (hypertensive renal disease)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Muscle cramps (painful sensations caused by muscle contraction)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Neck pain
Oedema lower limb (fluid collection in tissue of lower leg)
Overdose

50-59:

Breast cancer
Dyspnoea (difficult or laboured respiration)
Hepatocellular damage (liver damage)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Alopecia (absence of hair from areas of the body)
Chronic kidney disease
Disease progression
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)

60+:

Abdominal discomfort
Altered state of consciousness (altered state of mind)
Interstitial lung disease
Lymphocyte stimulation test positive
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased
Purpura (purplish discoloration of the skin)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
White blood cell count increased

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 13.16%
High Blood Pressure: 3 people, 7.89%
Depression: 3 people, 7.89%
Pain: 2 people, 5.26%
Musculoskeletal Discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 2 people, 5.26%
Maternal Therapy To Enhance Foetal Lung Maturity: 2 people, 5.26%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 2 people, 5.26%
Inflammatory Carcinoma Of The Breast: 2 people, 5.26%
High Blood Cholesterol: 2 people, 5.26%
Headache (pain in head): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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