Zantac and Uptravi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zantac (ranitidine hydrochloride) and Uptravi (selexipag). Common drug interactions include abdominal pain upper among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zantac and Uptravi. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

On Jul, 06, 2026

58 people who take Zantac and Uptravi together, and have interactions are studied.

What are the common drug interactions of Zantac and Uptravi, by gender? *:

female:

Abdominal pain upper
Fluid overload (too much fluid in the blood)
Influenza
Lymphadenopathy (disease or enlargement of lymph nodes)
Osteoporosis (bones weak and more likely to break)
Hospitalisation
Pain
Pain in extremity
Pulmonary hypertension (increase in blood pressure in the lung artery)
Stent placement

male:

Diarrhoea
Headache (pain in head)
Limb discomfort (discomfort in leg)
Oedema peripheral (superficial swelling)
White blood cell count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Back pain
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Dysphemia (stammering or stuttering)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Zantac and Uptravi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Arrhythmia (irregular heartbeat)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Dyspnoea (difficult or laboured respiration)
Oropharyngeal pain
Right atrial dilatation (enlargement of the right atrium chamber of heart)
Right ventricular dysfunction
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

20-29:

n/a

30-39:

Headache (pain in head)
Hospitalisation
Migraine (headache)

40-49:

Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Vomiting
Abdominal distension
Abdominal pain
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hypertension (high blood pressure)
Sinusitis (inflammation of sinus)

50-59:

Abdominal pain
Abdominal pain upper
Arthralgia (joint pain)
Blood creatinine increased
Blood glucose increased
Blood pressure increased
Blood urine present
Breast cancer stage iii
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)

60+:

Diarrhoea
Vomiting
Oxygen saturation decreased
Blood creatinine increased
Haemoglobin decreased
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Localised oedema (fluid retention in a particular part of the body)
Pulmonary oedema (fluid accumulation in the lungs)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 40 people, 68.97%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 10.34%
Indigestion: 4 people, 6.90%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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