Zavesca and Onfi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zavesca (miglustat) and Onfi (clobazam). Common drug interactions include pneumonia among females and tachycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Zavesca and Onfi. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Zavesca?

Zavesca has active ingredients of miglustat. eHealthMe is studying from 1,208 Zavesca users. Check the latest studies of Zavesca.

What is Onfi?

Onfi has active ingredients of clobazam. It is often used in epilepsy. eHealthMe is studying from 7,809 Onfi users. Check the latest studies of Onfi.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

24 people who take Zavesca and Onfi together, and have interactions are studied.

What are the common drug interactions of Zavesca and Onfi, by gender? *:

female:

Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Acute respiratory distress syndrome
Acute respiratory failure
Atelectasis (partial or complete collapse of the lung)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Influenza

male:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Pyrexia (fever)
Back disorder
Death
Dehydration (dryness resulting from the removal of water)
Enterovirus infection
Feeding tube complication
General physical condition
Hypotension (abnormally low blood pressure)
Influenza

What are the common drug interactions of Zavesca and Onfi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Rhinovirus infection
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal distension
Death
Enterovirus infection
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Dyspnoea (difficult or laboured respiration)
Oxygen saturation decreased
Pyrexia (fever)
Urinary tract infection
Cardiac disorder
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Pneumonia
Rhinovirus infection
Dehydration (dryness resulting from the removal of water)

20-29:

Respiratory depression (respiration has a rate below 12 breaths)
Unresponsive to stimuli

30-39:

Pneumonia
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Lipidosis (disorder of lipid metabolism involving abnormal accumulation of lipids in the reticuloendothelial cells): 9 people, 37.50%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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