Zegerid and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zegerid (omeprazole; sodium bicarbonate) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include gastroenteritis viral among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Zegerid and Hydramine. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Zegerid?

Zegerid has active ingredients of omeprazole; sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,220 Zegerid users. Check the latest studies of Zegerid.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 11, 2026

59 people who take Zegerid and Hydramine together, and have interactions are studied.

Zegerid and Hydramine drug interactions.

What are the common drug interactions of Zegerid and Hydramine, by gender? *:

female:

Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Limb injury
Multiple allergies (allergy to multiple agents)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Seasonal allergy (allergic condition due to certain season)
Upper respiratory tract infection
Headache (pain in head)
Capillary fragility (lack in resistance of capillary)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Scratch

male:

Pyrexia (fever)
Fatigue (feeling of tiredness)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bone pain
Hypertension (high blood pressure)
Infection
Pain
Renal injury (kidney injury)
Arthralgia (joint pain)
Back pain

What are the common drug interactions of Zegerid and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Oral infection
Pneumonia
Renal cyst (kidney cyst)
Tooth infection
Renal impairment (severely reduced kidney function)
Influenza
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Renal injury (kidney injury)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Benign prostatic hyperplasia (benign enlargement of the prostate)

60+:

Sinusitis (inflammation of sinus)
Asthma
Hypersensitivity
Diarrhoea
Swelling
Arthralgia (joint pain)
Back pain
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 29 people, 49.15%
Primary Immunodeficiency Syndrome: 8 people, 13.56%
High Blood Pressure: 7 people, 11.86%
Depression: 6 people, 10.17%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 6 people, 10.17%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 6 people, 10.17%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 10.17%
Immunodeficiency: 5 people, 8.47%
Combined Immunodeficiency: 5 people, 8.47%
Pain: 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

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