Zelboraf and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zelboraf (vemurafenib) and Methotrexate (methotrexate sodium). Common drug interactions include headache among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Zelboraf and Methotrexate. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zelboraf?

Zelboraf has active ingredients of vemurafenib. eHealthMe is studying from 8,392 Zelboraf users. Check the latest studies of Zelboraf.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 10, 2026

12 people who take Zelboraf and Methotrexate together, and have interactions are studied.

Zelboraf and Methotrexate drug interactions.

What are the common drug interactions of Zelboraf and Methotrexate, by gender? *:

female:

Headache (pain in head)
Dry skin
Intraocular pressure increased
Retinal haemorrhage (bleeding from retina)
Decreased appetite
Pain
Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood sodium decreased

male:

Asthenia (weakness)
Blood disorder
Acute lymphocytic leukaemia (cancer of the white blood cells)
Synovitis (inflammation of the synovial membrane)
Decreased appetite
Dysgeusia (disorder of the sense of taste)
Dyspepsia (indigestion)
Fluid intake reduced
Hypophagia (reduced food intake)
Lymphopenia (an abnormally low level of lymphocytes in the blood)

What are the common drug interactions of Zelboraf and Methotrexate, by age (0-1 to 60+)? *:

0-1:

Acute respiratory failure
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Venoocclusive liver disease (small veins in the liver are obstructed)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Synovitis (inflammation of the synovial membrane)

40-49:

n/a

50-59:

Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Photosensitivity reaction

60+:

Lymphopenia (an abnormally low level of lymphocytes in the blood)
Pneumonia
Acute lymphocytic leukaemia (cancer of the white blood cells)
Fall

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 6 people, 50.00%
Uveitis (inflammation of the uvea): 2 people, 16.67%
Sunburn: 2 people, 16.67%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 2 people, 16.67%
Histiocytosis (a blood disease characterized by an abnormal multiplication of macrophages): 2 people, 16.67%
Essential Hypertension (primary hypertension): 2 people, 16.67%
Bone Marrow Conditioning Regimen: 2 people, 16.67%
Alopecia Scarring (irreversible damage of the hair follicles, replacing them with scar tissue): 2 people, 16.67%
Alopecia Areata (patchy baldness that typically begins with rapid hair loss): 2 people, 16.67%
White Blood Cell Count Abnormal: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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