Zelnorm and Clonidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zelnorm (tegaserod maleate) and Clonidine (clonidine). Common drug interactions include pain in extremity among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zelnorm and Clonidine. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

91 people who take Zelnorm and Clonidine together, and have interactions are studied.

Zelnorm and Clonidine drug interactions.

What are the common drug interactions of Zelnorm and Clonidine, by gender? *:

female:

Pain in extremity
Actinomycosis (infection that causes sores, or abscesses)
Back pain
Bone disorder
Bone pain
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac failure congestive
Cerebral atrophy (decrement in size of brain)
Decreased interest
Fracture nonunion (permanent failure of healing following a broken bone)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dyspnoea (difficult or laboured respiration)
Urinary tract infection
Abdominal distension
Abdominal pain
Acute myocardial infarction (acute heart attack)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

What are the common drug interactions of Zelnorm and Clonidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gallbladder disorder
Obesity (having too much body fat)

40-49:

Pain
Anxiety
Respiratory failure (inadequate gas exchange by the respiratory system)
Vomiting
Weight decreased
Headache (pain in head)
Injury
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Sinusitis (inflammation of sinus)

50-59:

Constipation
Abdominal pain upper
Arteriosclerosis (thickening and hardening of arteries)
Asthma
Atelectasis (partial or complete collapse of the lung)
Cardiac murmur (an heart sound in valve abnormality)
Cardiomyopathy (weakening of the heart muscle)
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diplopia (double vision)

60+:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Irritable bowel syndrome
Muscle spasms (muscle contraction)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Back pain
Blood creatine phosphokinase increased
Blood creatine phosphokinase mb increased
Cardiac failure congestive
Cardiac flutter (abnormal heart rhythm)

What are the existing conditions these people have? *

Pain: 16 people, 17.58%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 17.58%
Irritable Bowel Syndrome: 14 people, 15.38%
High Blood Cholesterol: 13 people, 14.29%
Type 2 Diabetes: 10 people, 10.99%
Constipation: 10 people, 10.99%
Nuclear Magnetic Resonance Imaging Brain: 6 people, 6.59%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 6.59%
Breast Cancer: 6 people, 6.59%
Impaired Gastric Emptying: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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