Zemplar and Azathioprine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zemplar (paricalcitol) and Azathioprine (azathioprine sodium). Common drug interactions include low turnover osteopathy among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zemplar and Azathioprine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Zemplar?

Zemplar has active ingredients of paricalcitol. It is often used in kidney disease. eHealthMe is studying from 15,494 Zemplar users. Check the latest studies of Zemplar.

What is Azathioprine?

Azathioprine has active ingredients of azathioprine sodium. It is often used in crohn's disease. eHealthMe is studying from 60,623 Azathioprine users. Check the latest studies of Azathioprine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

28 people who take Zemplar and Azathioprine together, and have interactions are studied.

Zemplar and Azathioprine drug interactions.

What are the common drug interactions of Zemplar and Azathioprine, by gender? *:

female:

Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Lumbar radiculopathy (radicular pain in the low back and legs)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)
Pruritus (severe itching of the skin)

male:

Diarrhoea
Device related infection
Ejection fraction decreased (systolic heart failure)
Erythema multiforme (a type of hypersensitivity reaction)
Haemorrhage subepidermal (bleeding from the skin)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)
Skin disorder (skin disease)
Spinal osteoarthritis (joint cartilage loss in spine)
Anxiety

What are the common drug interactions of Zemplar and Azathioprine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Device related infection
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Muscle tightness

30-39:

n/a

40-49:

Anxiety
Skin disorder (skin disease)
Dry skin
Emotional distress
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Injury
Joint range of motion decreased (disease of joint movement)
Mobility decreased (ability to move is reduced)

50-59:

Face oedema (swelling of face)
Hypertension (high blood pressure)
Oedema peripheral (superficial swelling)

60+:

Chronic kidney disease
Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Diarrhoea
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Device related infection
Spinal osteoarthritis (joint cartilage loss in spine)

What are the existing conditions these people have? *

Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 6 people, 21.43%
Immunodeficiency Common Variable: 4 people, 14.29%
High Blood Pressure: 4 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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