Zenapax and Methotrexate drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Zenapax (daclizumab) and Methotrexate (methotrexate sodium). Common drug interactions include sleep disorder due to general medical condition, insomnia type among females and bacterial sepsis among males.
The phase IV clinical study analyzes what interactions people have when they take Zenapax and Methotrexate. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.
What is Zenapax?
Zenapax has active ingredients of daclizumab. eHealthMe is studying from 1,314 Zenapax users. Check the latest studies of Zenapax.
What is Methotrexate?
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.
14 people who take Zenapax and Methotrexate together, and have interactions are studied.

What are the common drug interactions of Zenapax and Methotrexate, by gender? *:
female:
- Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
- Transplant rejection (a transplant material is not worked)
- Acute hepatic failure
- Drug level decreased
- Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
- Drug ineffective
- Acne (skin problems that cause pimples)
- Alopecia (absence of hair from areas of the body)
- Ovarian cyst (fluid filled sac of the ovary)
- Overdose
male:
- Bacterial sepsis
- Gastrointestinal toxicity (damage to digestive tract by any substance)
- Hepatotoxicity (chemical-driven liver damage)
What are the common drug interactions of Zenapax and Methotrexate, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Acute hepatic failure
- Bacterial sepsis
- Gastrointestinal toxicity (damage to digestive tract by any substance)
- Hepatotoxicity (chemical-driven liver damage)
10-19:
- Drug level decreased
- Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
20-29:
- Drug ineffective
30-39:
n/a
40-49:
- Acne (skin problems that cause pimples)
- Alopecia (absence of hair from areas of the body)
- Drug ineffective
- Ovarian cyst (fluid filled sac of the ovary)
- Overdose
- Pain
- Pneumonia
- Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
- Transplant rejection (a transplant material is not worked)
50-59:
n/a
60+:
n/a
What are the existing conditions these people have? *
- Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 28.57%
- Transplant Rejection (a transplant material is not worked): 2 people, 14.29%
- Strongyloidiasis (infection with strongyloides stercoralis): 2 people, 14.29%
- Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 2 people, 14.29%
- Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 1 person, 7.14%
* Approximation only. Some reports may have incomplete information.
Do you take Zenapax and Methotrexate?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Zenapax (1,314 reports)
- Methotrexate (604,313 reports)
Browse all drug interactions of Zenapax and Methotrexate:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Zenapax:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Methotrexate:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zenapax and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Methotrexate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
How the study uses the data?
The study uses data from the FDA. It is based on daclizumab and methotrexate sodium (the active ingredients of Zenapax and Methotrexate, respectively), and Zenapax and Methotrexate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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