Zenatane and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zenatane (isotretinoin) and Singulair (montelukast sodium). Common drug interactions include arthralgia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Zenatane and Singulair. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Zenatane?

Zenatane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 5,688 Zenatane users. Check the latest studies of Zenatane.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

On Jul, 09, 2026

23 people who take Zenatane and Singulair together, and have interactions are studied.

Zenatane and Singulair drug interactions.

What are the common drug interactions of Zenatane and Singulair, by gender? *:

female:

Arthralgia (joint pain)
Constipation
Joint dislocation (a joint position is changed from normal position)
Affect lability (emotional incontinence)
Anxiety
Aspartate aminotransferase increased
Back pain
Blood pressure increased
Chest discomfort
Depression

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Mood altered (changes in mood)
Mood swings (an extreme or rapid change in mood)
Abdominal pain upper
Depression
Drug ineffective
Retching (strong involuntary effort to vomit)
Vomiting
Chronic kidney disease

What are the common drug interactions of Zenatane and Singulair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal behaviour
Anger
Mood altered (changes in mood)
Mood swings (an extreme or rapid change in mood)
Affect lability (emotional incontinence)
Anxiety
Depression
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Suicidal ideation

20-29:

Chest discomfort
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Wheezing (a high-pitched whistling sound made while you breath)

30-39:

n/a

40-49:

n/a

50-59:

Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Multiple injuries
Nausea (feeling of having an urge to vomit)
Pain
Retching (strong involuntary effort to vomit)
Vomiting

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 26.09%
Hypersensitivity: 2 people, 8.70%
Acne Cystic (skin problems that cause pimples): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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