Zestoretic and Abilify drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Abilify (aripiprazole). Common drug interactions include discomfort among females and dysarthria among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Abilify. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

On Jul, 09, 2026

54 people who take Zestoretic and Abilify together, and have interactions are studied.

Zestoretic and Abilify drug interactions.

What are the common drug interactions of Zestoretic and Abilify, by gender? *:

female:

Discomfort
Drug dependence
Drug hypersensitivity
Ear infection
Erythema (redness of the skin)
Fall
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haematocrit increased
Haematoma (collection of blood outside the blood vessels)
Haemoglobin increased

male:

Dysarthria (speech disorder)
Hypokalaemia (low potassium)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Agitation (state of anxiety or nervous excitement)
Anuria (failure of the kidneys to produce urine)
Asthenia (weakness)
Blood creatinine increased
Blood urea increased
Drug ineffective

What are the common drug interactions of Zestoretic and Abilify, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Affective disorder (mental disorder)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Blood glucose increased
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

30-39:

n/a

40-49:

Dysarthria (speech disorder)
Hypokalaemia (low potassium)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Asthenia (weakness)
Headache (pain in head)
Confusional state
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Anuria (failure of the kidneys to produce urine)
White blood cell count increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

50-59:

Nausea (feeling of having an urge to vomit)
Agitation (state of anxiety or nervous excitement)
Dysarthria (speech disorder)
Hypokalaemia (low potassium)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Insomnia (sleeplessness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pain
Speech disorder
Abdominal discomfort

60+:

Mixed liver injury
Asthenia (weakness)
Haemorrhage (bleeding)
Left ventricular dysfunction
Lipids increased (excess lipid in body)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Type 2 diabetes mellitus
Weight increased
Blood creatinine increased
Blood urea increased

What are the existing conditions these people have? *

Menopausal Symptoms: 15 people, 27.78%
Bipolar Disorder (mood disorder): 14 people, 25.93%
Insomnia (sleeplessness): 11 people, 20.37%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 10 people, 18.52%
Post-Traumatic Stress Disorder: 10 people, 18.52%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 16.67%
Seasonal Allergy (allergic condition due to certain season): 8 people, 14.81%
High Blood Cholesterol: 4 people, 7.41%
Hot Flush (sudden feelings of heat): 4 people, 7.41%
Stress And Anxiety: 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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