Zestoretic and Azithromycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Azithromycin (azithromycin). Common drug interactions include lethargy among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Azithromycin. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Azithromycin?

Azithromycin has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 40,716 Azithromycin users. Check the latest studies of Azithromycin.

On Jul, 08, 2026

15 people who take Zestoretic and Azithromycin together, and have interactions are studied.

Zestoretic and Azithromycin drug interactions.

What are the common drug interactions of Zestoretic and Azithromycin, by gender? *:

female:

Lethargy (tiredness)
Loss of consciousness
Memory impairment
Mood altered (changes in mood)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oesophageal stenosis (narrowing of oesophagus)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Periventricular leukomalacia (white-matter brain injury)
Personality change

male:

Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain
Drug ineffective
Ear pain
Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Heart valve incompetence (heart's valves do not work correctly)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)

What are the common drug interactions of Zestoretic and Azithromycin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal hypertension (high blood pressure caused by the kidneys hormonal response)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

Abdominal discomfort
Abdominal distension
Blood creatinine increased
Diarrhoea
Impaired work ability
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Vomiting

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Drug ineffective
Ear pain
Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Heart valve incompetence (heart's valves do not work correctly)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 40.00%
Pain: 4 people, 26.67%
High Blood Cholesterol: 3 people, 20.00%
Gastric Ulcer (stomach ulcer): 2 people, 13.33%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 13.33%
Impaired Gastric Emptying: 2 people, 13.33%
Infection: 2 people, 13.33%
Multiple Allergies (allergy to multiple agents): 2 people, 13.33%
Gout (uric acid crystals building up in the body): 2 people, 13.33%
Nausea (feeling of having an urge to vomit): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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