Zestoretic and Cipro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Cipro (ciprofloxacin hydrochloride). Common drug interactions include nephrogenic anaemia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Cipro. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Cipro?

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 35,126 Cipro users. Check the latest studies of Cipro.

On Jul, 27, 2026

31 people who take Zestoretic and Cipro together, and have interactions are studied.

What are the common drug interactions of Zestoretic and Cipro, by gender? *:

female:

Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)
Shoulder operation
Vision blurred
Cough
Abdominal pain
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Accident
Acute myocardial infarction (acute heart attack)
Anoxic encephalopathy (brain damage due to lack of oxygen)
Arthralgia (joint pain)
Asthma
Back pain
Blindness unilateral
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the common drug interactions of Zestoretic and Cipro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Accident
Arthralgia (joint pain)
Asthma
Back pain
Blindness unilateral
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cataract (clouding of the lens inside the eye)
Chest tenderness (painful chest on touch)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

50-59:

Abdominal pain
Dehydration (dryness resulting from the removal of water)
Nausea (feeling of having an urge to vomit)
Vomiting
Papillary thyroid cancer
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Chest pain
Chronic kidney disease
Diarrhoea
Emotional distress

60+:

Chronic kidney disease
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Rectal haemorrhage (bleeding from anus)
Acute myocardial infarction (acute heart attack)
Alopecia (absence of hair from areas of the body)
Anoxic encephalopathy (brain damage due to lack of oxygen)
Breast pain
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysphagia (a condition in which swallowing is difficult or painful)

What are the existing conditions these people have? *

Pain: 6 people, 19.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.13%
Depression: 4 people, 12.90%
Nausea (feeling of having an urge to vomit): 3 people, 9.68%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.68%
Diabetes: 3 people, 9.68%
Itching: 3 people, 9.68%
Stress And Anxiety: 3 people, 9.68%
High Blood Cholesterol: 3 people, 9.68%
Type 2 Diabetes: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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