Zestoretic and Dilaudid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Dilaudid (hydromorphone hydrochloride). Common drug interactions include blood glucose increased among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Dilaudid. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

On Jul, 08, 2026

26 people who take Zestoretic and Dilaudid together, and have interactions are studied.

Zestoretic and Dilaudid drug interactions.

What are the common drug interactions of Zestoretic and Dilaudid, by gender? *:

female:

Blood glucose increased
Bone pain
Fall
Fatigue (feeling of tiredness)
Urinary tract infection
Abdominal discomfort
Abdominal pain upper
Abscess limb (limb infection)
Alanine aminotransferase increased
Aspartate aminotransferase increased

male:

Dyspnoea (difficult or laboured respiration)
Abdominal distension
Cardiogenic shock (inadequate circulation of blood)
Cellulitis (infection under the skin)
Diarrhoea
Dizziness
Fluid overload (too much fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematocrit decreased
Haematuria (presence of blood in urine)

What are the common drug interactions of Zestoretic and Dilaudid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fluid overload (too much fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematuria (presence of blood in urine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperkalaemia (damage to or disease of the kidney)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypoxia (low oxygen in tissues)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)

60+:

Abdominal pain
Blood creatinine increased
Pancreatitis acute (sudden inflammation of pancreas)
Peripheral swelling
Red blood cell sedimentation rate increased
Weight decreased
Blood glucose increased
Chest pain
Diarrhoea
Dry mouth

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 5 people, 19.23%
Dehydration (dryness resulting from the removal of water): 5 people, 19.23%
Pulmonary Embolism (blockage of the main artery of the lung): 5 people, 19.23%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 19.23%
Cellulitis (infection under the skin): 4 people, 15.38%
Constipation: 4 people, 15.38%
Stress And Anxiety: 3 people, 11.54%
Sleep Disorder: 3 people, 11.54%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 11.54%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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