Zestoretic and Folvite drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Folvite (folic acid). Common drug interactions include arthralgia among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Folvite. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Folvite?

Folvite has active ingredients of folic acid. eHealthMe is studying from 2,529 Folvite users. Check the latest studies of Folvite.

On Jul, 08, 2026

15 people who take Zestoretic and Folvite together, and have interactions are studied.

Zestoretic and Folvite drug interactions.

What are the common drug interactions of Zestoretic and Folvite, by gender? *:

female:

Arthralgia (joint pain)
Pain in extremity
Fall
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Asthma
Back pain
Contusion (a type of hematoma of tissue in which capillaries)
Dry skin
Hypokalaemia (low potassium)
Immunodeficiency

male:

Blood creatinine increased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Lactic acidosis (low ph in body tissues)
Neutropenia (an abnormally low number of neutrophils)
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Weight decreased

What are the common drug interactions of Zestoretic and Folvite, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Arthralgia (joint pain)
Pain in extremity
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Immunodeficiency
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Lactic acidosis (low ph in body tissues)
Neutropenia (an abnormally low number of neutrophils)

What are the existing conditions these people have? *

Pain: 5 people, 33.33%
Nausea (feeling of having an urge to vomit): 4 people, 26.67%
Stress And Anxiety: 3 people, 20.00%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 13.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 13.33%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 2 people, 13.33%
Pleural Mesothelioma Malignant (cancer of the pleura, or the membrane that lines the lungs): 2 people, 13.33%
Nausea And Vomiting: 2 people, 13.33%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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