Zestoretic and Glimepiride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Glimepiride (glimepiride). Common drug interactions include hypotension among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Glimepiride. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Glimepiride?

Glimepiride has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 45,909 Glimepiride users. Check the latest studies of Glimepiride.

On Jul, 16, 2026

38 people who take Zestoretic and Glimepiride together, and have interactions are studied.

Zestoretic and Glimepiride drug interactions.

What are the common drug interactions of Zestoretic and Glimepiride, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain
Papillary thyroid cancer
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Vomiting

male:

Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypotension (abnormally low blood pressure)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Vomiting
5-hydroxyindolacetic acid in urine increased (increased serotonin levels)
Abdominal discomfort

What are the common drug interactions of Zestoretic and Glimepiride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alcoholism (problems with alcohol)
Depression
Diabetes mellitus inadequate control
Diabetes with hyperosmolarity (diabetes with increasing blood glucose levels and dehydration)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Glycosylated haemoglobin increased
Headache (pain in head)
Heart rate irregular
Hyperlipidaemia (presence of excess lipids in the blood)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Papillary thyroid cancer
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Alopecia (absence of hair from areas of the body)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Dyspepsia (indigestion)
Hair colour changes

60+:

Respiratory failure (inadequate gas exchange by the respiratory system)
Vomiting
Gastric cancer (stomach cancer)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Dysphagia (a condition in which swallowing is difficult or painful)
Hypotension (abnormally low blood pressure)
Lip swelling

What are the existing conditions these people have? *

Type 2 Diabetes: 16 people, 42.11%
High Blood Cholesterol: 5 people, 13.16%
Pain: 5 people, 13.16%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 13.16%
Stress And Anxiety: 4 people, 10.53%
Infection: 4 people, 10.53%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 7.89%
Rashes (redness): 3 people, 7.89%
Pain In Extremity: 3 people, 7.89%
Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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