Zestril and Librium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestril (lisinopril) and Librium (chlordiazepoxide hydrochloride). Common drug interactions include dyspepsia among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Zestril and Librium. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

On Jul, 10, 2026

23 people who take Zestril and Librium together, and have interactions are studied.

What are the common drug interactions of Zestril and Librium, by gender? *:

female:

Dyspepsia (indigestion)
Dysuria (painful or difficult urination)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gout (uric acid crystals building up in the body)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Head injury
Headache (pain in head)

male:

Confusional state
Weight decreased
Hallucination (an experience involving the perception of something not present)
Hepatic steatosis (fatty liver disease)
Hepatomegaly (abnormal enlargement of the liver)
Infection
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscle atrophy (a decrease in the mass of the muscle)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Pulmonary congestion (congestion in the lungs)

What are the common drug interactions of Zestril and Librium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Type 2 diabetes mellitus
Alopecia (absence of hair from areas of the body)
Eye disorder
Retinopathy diabetic (acute damage to the retina of the eye due to diabetes)

30-39:

n/a

40-49:

Accidental death
Aphasia (damage to the parts of the brain that control language)
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coma (state of unconsciousness lasting more than six hours)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Hepatic steatosis (fatty liver disease)

50-59:

Dyspnoea (difficult or laboured respiration)
Eructation (release of gas from the digestive tract)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Insomnia (sleeplessness)
Malignant neoplasm progression (cancer tumour came back)
Nausea (feeling of having an urge to vomit)
Pain
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain

60+:

Cardiac murmur (an heart sound in valve abnormality)
Electrocardiogram abnormal
Apathy
Aphasia (damage to the parts of the brain that control language)
Arteriosclerosis (thickening and hardening of arteries)
Atopy (a genetic disposition to develop an allergic reaction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block first degree (heart block first degree)
Back pain
Blood cholesterol increased

What are the existing conditions these people have? *

Quit Smoking: 3 people, 13.04%
Bipolar Disorder (mood disorder): 3 people, 13.04%
Depression: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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