Ziac and Pradaxa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ziac (bisoprolol fumarate; hydrochlorothiazide) and Pradaxa (dabigatran etexilate mesylate). Common drug interactions include gastrointestinal haemorrhage among females and upper gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Ziac and Pradaxa. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

What is Pradaxa?

Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 86,906 Pradaxa users. Check the latest studies of Pradaxa.

On Aug, 09, 2026

36 people who take Ziac and Pradaxa together, and have interactions are studied.

What are the common drug interactions of Ziac and Pradaxa, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)
Throat irritation
Contusion (a type of hematoma of tissue in which capillaries)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Pain in extremity
Pneumonia
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Back pain
Blood urea increased

male:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Haematemesis (vomiting of blood)
Flatulence (flatus expelled through the anus)
Gout (uric acid crystals building up in the body)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)
Vision blurred
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Groin abscess (pus in groin)

What are the common drug interactions of Ziac and Pradaxa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Pain in extremity

60+:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Diarrhoea
Dizziness
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Gout (uric acid crystals building up in the body)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Insomnia (sleeplessness)
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

High Blood Cholesterol: 11 people, 30.56%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 13.89%
Diabetes: 5 people, 13.89%
Stress And Anxiety: 4 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 11.11%
Cardiac Disorder: 4 people, 11.11%
Haematemesis (vomiting of blood): 3 people, 8.33%
Depression: 3 people, 8.33%
Menopause (end of monthly cycles in women): 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ziac and Pradaxa?

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