Zide and Phosphosoda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Phosphosoda (sodium phosphates). Common drug interactions include agitation among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Phosphosoda. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Phosphosoda?

Phosphosoda has active ingredients of sodium phosphates. eHealthMe is studying from 1,327 Phosphosoda users. Check the latest studies of Phosphosoda.

On Jul, 26, 2026

63 people who take Zide and Phosphosoda together, and have interactions are studied.

What are the common drug interactions of Zide and Phosphosoda, by gender? *:

female:

Agitation (state of anxiety or nervous excitement)
Anaemia of chronic disease
Angioedema (rapid swelling of the dermis)
Anuria (failure of the kidneys to produce urine)
Arterial injury
Arthropathy
Atelectasis (partial or complete collapse of the lung)
Blood glucose increased
Blood parathyroid hormone increased
Blood pressure decreased

male:

Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypotension (abnormally low blood pressure)
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased)
Nephropathy (damage to or disease of a kidney)

What are the common drug interactions of Zide and Phosphosoda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Renal failure chronic (long lasting kidney dysfunction)
Anaemia (lack of blood)
Arthralgia (joint pain)
Carcinoid syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction)
Diarrhoea
Dizziness
Drug toxicity
Eating disorder
Hypokalaemia (low potassium)
Hypovolaemia (a decreased volume of circulating blood in the body)

40-49:

Nephrosclerosis (hardening of the kidney due to renovascular disease)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)

50-59:

Dysgeusia (disorder of the sense of taste)
Headache (pain in head)
Acute phosphate nephropathy (sudden damage to the kidneys caused by the formation of phosphate crystals)
Asthenia (weakness)
Blood erythropoietin decreased
Blood phosphorus increased
Blood pressure decreased
Dehydration (dryness resulting from the removal of water)
Hypophagia (reduced food intake)
Hypotension (abnormally low blood pressure)

60+:

Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypovolaemia (a decreased volume of circulating blood in the body)
Malaise (a feeling of general discomfort or uneasiness)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Acute phosphate nephropathy (sudden damage to the kidneys caused by the formation of phosphate crystals)
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

* Approximation only. Some reports may have incomplete information.

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