Zocor and Emend drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zocor (simvastatin) and Emend (aprepitant). Common drug interactions include malaise among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Zocor and Emend. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Zocor?

Zocor has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 86,545 Zocor users. Check the latest studies of Zocor.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

47 people who take Zocor and Emend together, and have interactions are studied.

What are the common drug interactions of Zocor and Emend, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Pulmonary embolism (blockage of the main artery of the lung)
Alopecia (absence of hair from areas of the body)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Fatigue (feeling of tiredness)
Feeling hot
Hair colour changes

male:

Death
Metastases to spine (cancer spreads to spine)
Neuropathy peripheral (surface nerve damage)
Oral candidiasis (fungal infection of mouth)
Ataxia (loss of full control of bodily movements)
Confusional state
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Fatigue (feeling of tiredness)

What are the common drug interactions of Zocor and Emend, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Calcium deficiency (lack of calcium)
Cardiovascular disorder (heart diseases)
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cluster headache (one-sided head pain with tearing)
Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glaucoma (increased fluid pressure in the eye with vision loss)
Gout (uric acid crystals building up in the body)

40-49:

Hypotension (abnormally low blood pressure)
Vomiting
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Feeling hot
Hyperhidrosis (abnormally increased sweating)
Lethargy (tiredness)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Abdominal discomfort
Abdominal distension

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder obstruction
Blood glucose increased
Blood pressure systolic increased
Bone density decreased
Bone disorder
Cardiac murmur (an heart sound in valve abnormality)
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

60+:

Death
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Confusional state
Diarrhoea
Electrolyte imbalance
Epistaxis (bleed from the nose)
Neutropenia (an abnormally low number of neutrophils)
Pleural effusion (water on the lungs)
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Pain: 5 people, 10.64%
Lung Neoplasm Malignant (cancer tumour of lung): 5 people, 10.64%
Diabetes: 5 people, 10.64%
Breast Cancer Female: 5 people, 10.64%
Thrombocytopenia (decrease of platelets in blood): 4 people, 8.51%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 8.51%
Anaemia (lack of blood): 4 people, 8.51%
Urination - Excessive Volume: 3 people, 6.38%
Stable Angina (a constant chest pain): 3 people, 6.38%
Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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