Zofran odt and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran odt (ondansetron) and Oxycontin (oxycodone hydrochloride). Common drug interactions include skin burning sensation among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran odt and Oxycontin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran odt?

Zofran odt has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 2,092 Zofran odt users. Check the latest studies of Zofran odt.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

On Jul, 26, 2026

35 people who take Zofran odt and Oxycontin together, and have interactions are studied.

Zofran odt and Oxycontin drug interactions.

What are the common drug interactions of Zofran Odt and Oxycontin, by gender? *:

female:

Skin burning sensation
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Surgery
Thrombocytopenia (decrease of platelets in blood)
Vitamin d decreased
Drug hypersensitivity
Pathological fracture (broken bone caused by disease)
Gastritis (inflammation of stomach)
Anxiety

male:

Fatigue (feeling of tiredness)
Death
Hypersomnia (excessive daytime sleepiness (eds))
Acne (skin problems that cause pimples)
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Dysgeusia (disorder of the sense of taste)
Hair colour changes
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Arthralgia (joint pain)
Bone disorder

What are the common drug interactions of Zofran Odt and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Depression
Drug ineffective
Hyperphagia (an abnormal appetite for food)
Overweight
Post-traumatic stress disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

40-49:

Anaemia of malignant disease
Arthralgia (joint pain)
Blood iron decreased
Bone pain
Cachexia (loss of weight)
Depression
Disease progression
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)

50-59:

Gastritis (inflammation of stomach)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Multiple myeloma (cancer of the plasma cells)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Death
Diarrhoea
Enterocolitis infectious
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Pancreatitis acute (sudden inflammation of pancreas)

60+:

Drug hypersensitivity
Pathological fracture (broken bone caused by disease)
Hair colour changes
Anaemia (lack of blood)
Arthralgia (joint pain)
Bone disorder
Bradycardia (abnormally slow heart action)
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 14.29%
Insomnia (sleeplessness): 5 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Nausea And Vomiting: 2 people, 5.71%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 5.71%
Dry Eyes (lack of adequate tears): 2 people, 5.71%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 2 people, 5.71%
Back Pain: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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