Zofran odt and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran odt (ondansetron) and Ultram (tramadol hydrochloride). Common drug interactions include fatigue among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran odt and Ultram. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran odt?

Zofran odt has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 2,092 Zofran odt users. Check the latest studies of Zofran odt.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 07, 2026

33 people who take Zofran odt and Ultram together, and have interactions are studied.

Zofran odt and Ultram drug interactions.

What are the common drug interactions of Zofran Odt and Ultram, by gender? *:

female:

Fatigue (feeling of tiredness)
Pain in extremity
Disease progression
Nervousness
Pericardial effusion (fluid around the heart)
Peripheral swelling
Pleural effusion (water on the lungs)
Accident
Nerve injury
Bone pain

male:

Asthenia (weakness)
Blood glucose increased
Fatigue (feeling of tiredness)
Migraine (headache)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Chronic myelomonocytic leukaemia (cancers of the blood-forming cells of the bone marrow)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Zofran Odt and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Drug ineffective
Drug resistance (reduction in effectiveness of a drug)
Emotional distress
Foot fracture
Hand fracture
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

30-39:

Asthenia (weakness)
Bone pain
Cardiomyopathy (weakening of the heart muscle)
Constipation
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Metastases to skin (cancer spreads to skin)
Mobility decreased (ability to move is reduced)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

40-49:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection

50-59:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Abdominal pain upper
Diarrhoea
Fatigue (feeling of tiredness)

60+:

Disease progression
Nervousness
Insomnia (sleeplessness)
Blood glucose increased
Discomfort
Glycosylated haemoglobin increased
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Visual impairment
Diarrhoea

What are the existing conditions these people have? *

Nausea And Vomiting: 7 people, 21.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 15.15%
Blood Pressure Abnormal: 5 people, 15.15%
Neuralgia (pain in one or more nerves): 5 people, 15.15%
Nerve Injury: 5 people, 15.15%
Multiple Myeloma (cancer of the plasma cells): 5 people, 15.15%
Depression: 5 people, 15.15%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 12.12%
Cryptococcosis (potentially fatal fungal disease): 3 people, 9.09%
Hiv Infection: 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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