Zofran and Accutane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Accutane (isotretinoin). Common drug interactions include abdominal discomfort among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Accutane. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

On Jul, 13, 2026

33 people who take Zofran and Accutane together, and have interactions are studied.

What are the common drug interactions of Zofran and Accutane, by gender? *:

female:

Abdominal discomfort
Stress
Hepatic enzyme increased
Inflammatory bowel disease
Injection site bruising
Streptococcal infection
Subcutaneous abscess
Abscess (pus)
Depression
Irritable bowel syndrome

male:

Inflammatory bowel disease
Pain
Small intestinal obstruction (blockage in small intestine)
Insulin-like growth factor decreased
Irritability
Abdominal distension
Abdominal pain
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Alveolar osteitis (complication of wound healing following extraction of a tooth)

What are the common drug interactions of Zofran and Accutane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Back pain
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dyspepsia (indigestion)
Inflammatory bowel disease
Irritable bowel syndrome
Muscle spasms (muscle contraction)
Thrombosis (formation of a blood clot inside a blood vessel)
Bone pain
Insulin-like growth factor decreased

20-29:

Streptococcal infection
Stress
Subcutaneous abscess
Abscess (pus)
Swelling
Cholecystitis chronic (long lasting infection of gallbladder)
Small intestinal obstruction (blockage in small intestine)
Anxiety
Cholecystitis acute (rapid infection of gallbladder)
Emotional distress

30-39:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional disorder
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Local swelling (swelling at the site of some application of substance or injury)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain in extremity
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

40-49:

n/a

50-59:

Constipation
Dehydration (dryness resulting from the removal of water)
Depression
Inflammatory bowel disease
Abdominal discomfort
Abscess (pus)
Anaemia of chronic disease
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood cholesterol increased

60+:

Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Cholangitis sclerosing (infection and obstruction of bile duct)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diarrhoea
Emotional distress

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 18.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 12.12%
Birth Control: 4 people, 12.12%
Metastases To Bone (cancer spreads to bone): 3 people, 9.09%
Hypersensitivity: 3 people, 9.09%
Pain: 2 people, 6.06%
Acne Cystic (skin problems that cause pimples): 2 people, 6.06%
Back Pain: 2 people, 6.06%
Brain Neoplasm Malignant (brain cancer tumour): 2 people, 6.06%
Breast Cancer: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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