Zofran and Maxalt-mlt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Maxalt-mlt (rizatriptan benzoate). Common drug interactions include back pain among females and anticonvulsant drug level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Maxalt-mlt. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

On Jul, 09, 2026

95 people who take Zofran and Maxalt-mlt together, and have interactions are studied.

Zofran and Maxalt-mlt drug interactions.

What are the common drug interactions of Zofran and Maxalt-Mlt, by gender? *:

female:

Back pain
Dehydration (dryness resulting from the removal of water)
Abdominal pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Myalgia (muscle pain)
Pain in extremity
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vision blurred
Arthralgia (joint pain)

male:

Anticonvulsant drug level increased
Death
Back pain
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Zofran and Maxalt-Mlt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal distension
Erythema (redness of the skin)
Pain
Swelling
Urinary incontinence (inability to control the flow of urine and involuntary urination)

20-29:

Dizziness
Enuresis (repeated inability to control urination)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vision blurred
Visual field defect

30-39:

Fall
Ankle fracture
Asthenia (weakness)
Chest discomfort
Dizziness
Lower limb fracture
Muscle twitching
Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pain

40-49:

Chest pain
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Asthenia (weakness)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cerebral haemorrhage (bleeding within the brain)
Concussion (short loss of normal brain function in response to a head injury)
Dehydration (dryness resulting from the removal of water)

50-59:

Dysaesthesia (abnormal sensation)
Dysphemia (stammering or stuttering)
Eating disorder
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Emotional distress
Enterocolitis infectious
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
Exostosis (formation of new bone on the surface of a bone)
Face injury

60+:

Dizziness
Abdominal pain
Death
Drug ineffective
Eye pain
Gingival swelling (gums swelling)
Hyperhidrosis (abnormally increased sweating)
Loss of consciousness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Night sweats (sweating in night)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 31 people, 32.63%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 16.84%
Pain: 8 people, 8.42%
Stress And Anxiety: 7 people, 7.37%
Nausea And Vomiting: 7 people, 7.37%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 7.37%
Drowsiness: 6 people, 6.32%
Muscle Spasms (muscle contraction): 5 people, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Zofran and Maxalt-mlt?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously