Zofran and Norflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Norflex (orphenadrine citrate). Common drug interactions include contusion among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Norflex. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

On Aug, 01, 2026

76 people who take Zofran and Norflex together, and have interactions are studied.

What are the common drug interactions of Zofran and Norflex, by gender? *:

female:

Contusion (a type of hematoma of tissue in which capillaries)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Cellulitis (infection under the skin)
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenia (weakness)
Constipation

male:

Diarrhoea
Dehydration (dryness resulting from the removal of water)
Oedema peripheral (superficial swelling)
Paraplegia (paralysis of the legs and lower body)
Pneumonia
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Suicidal ideation
Urinary tract infection
Weight decreased
Headache (pain in head)

What are the common drug interactions of Zofran and Norflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pneumonia
Anxiety
Oedema peripheral (superficial swelling)
Urinary tract infection
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dehydration (dryness resulting from the removal of water)
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

30-39:

Gait disturbance
Influenza like illness
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Cellulitis (infection under the skin)
Heart rate increased
Hypertension (high blood pressure)
Anxiety
Back injury
Concussion (short loss of normal brain function in response to a head injury)
Confusional state

40-49:

Diarrhoea
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Depression
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal pain upper
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Chest discomfort
Ear pain
Fall

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Cough
Electrocardiogram qt prolonged
Hypophagia (reduced food intake)

60+:

Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Depression
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrolithiasis (calculi in the kidneys)
Photosensitivity reaction
Stress
Weight decreased

What are the existing conditions these people have? *

Pain: 7 people, 9.21%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 9.21%
Constipation: 6 people, 7.89%
Osteoporosis (bones weak and more likely to break): 5 people, 6.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.58%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.58%
Back Pain: 5 people, 6.58%
Migraine (headache): 4 people, 5.26%
High Blood Cholesterol: 4 people, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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