Zofran and Nulytely drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Nulytely (polyethylene glycol 3350; potassium chloride; sodium bicarbonate; sodium chloride). Common drug interactions include rapid correction of hyponatraemia among females and general physical health deterioration among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Nulytely. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Nulytely?

Nulytely has active ingredients of polyethylene glycol 3350; potassium chloride; sodium bicarbonate; sodium chloride. eHealthMe is studying from 1,377 Nulytely users. Check the latest studies of Nulytely.

On Jul, 25, 2026

35 people who take Zofran and Nulytely together, and have interactions are studied.

What are the common drug interactions of Zofran and Nulytely, by gender? *:

female:

Rapid correction of hyponatraemia (rapid correction of abnormally low concentrations of sodium ions in the circulating blood)
General physical health deterioration (weak health status)
Thirst
Blood sodium decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Joint dislocation (a joint position is changed from normal position)
Delirium (wild excitement)
Hallucination (an experience involving the perception of something not present)

male:

General physical health deterioration (weak health status)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Liver disorder (liver diseases)
Renal failure (kidney dysfunction)
Respiratory tract infection
Anaemia (lack of blood)
Aspartate aminotransferase increased
Atrial tachycardia (rhythm disturbance that arises in the atria)
Bacteraemia (presence of bacteria in the blood)
Bilirubin conjugated increased

What are the common drug interactions of Zofran and Nulytely, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Intestinal resection
Pouchitis (inflammatory bowel disease)

20-29:

Anal abscess
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Infusion related reaction
Lung transplant rejection (failure of lung transplant)
Quadriplegia (a four limb paralysis)

30-39:

n/a

40-49:

Paresis (a condition of muscular weakness)

50-59:

Chronic kidney disease
Diarrhoea
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypophagia (reduced food intake)
Incontinence (lack of moderation or self-control)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

60+:

General physical health deterioration (weak health status)
Decreased appetite
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Blood sodium decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Febrile neutropenia (fever with reduced white blood cells)
Joint dislocation (a joint position is changed from normal position)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased

What are the existing conditions these people have? *

Pain: 16 people, 45.71%
Bone Pain: 9 people, 25.71%
Multiple Myeloma (cancer of the plasma cells): 9 people, 25.71%
Nausea And Vomiting: 7 people, 20.00%
High Blood Pressure: 6 people, 17.14%
Constipation: 5 people, 14.29%
Sleep Disorder: 4 people, 11.43%
Depression: 4 people, 11.43%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 11.43%
Cerebral Disorder (brain disease): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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