Zofran and Prinzide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Prinzide (hydrochlorothiazide; lisinopril). Common drug interactions include breast cancer among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Prinzide. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

On Jul, 17, 2026

49 people who take Zofran and Prinzide together, and have interactions are studied.

What are the common drug interactions of Zofran and Prinzide, by gender? *:

female:

Breast cancer
Carbohydrate antigen 27.29 increased
Cataract (clouding of the lens inside the eye)
Contusion (a type of hematoma of tissue in which capillaries)
Ear infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal pain
Headache (pain in head)
Hypoacusis (loss of hearing)
Memory impairment

male:

Blood creatinine increased
Fatigue (feeling of tiredness)
Decreased appetite
Epistaxis (bleed from the nose)
Gastroenteritis escherichia coli (inflammation of stomach and intestine caused by escherichia coli infection)
Lactic acidosis (low ph in body tissues)
Polyp
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Acne (skin problems that cause pimples)
Adrenal mass

What are the common drug interactions of Zofran and Prinzide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

Cardiac arrest
Cardiogenic shock (inadequate circulation of blood)
Constipation
Diarrhoea
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Glioblastoma multiforme (most common and deadliest of malignant primary brain tumours in adults)
Headache (pain in head)
Irritability
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

60+:

Diarrhoea
Blood creatinine increased
Chronic kidney disease
Abdominal discomfort
Abdominal distension
Blood glucose increased
Epistaxis (bleed from the nose)
Gastroenteritis escherichia coli (inflammation of stomach and intestine caused by escherichia coli infection)
Lactic acidosis (low ph in body tissues)
Pneumonia

What are the existing conditions these people have? *

Pain: 12 people, 24.49%
Stress And Anxiety: 10 people, 20.41%
Nausea And Vomiting: 8 people, 16.33%
Constipation: 7 people, 14.29%
Type 2 Diabetes: 6 people, 12.24%
Sleep Disorder: 6 people, 12.24%
Diabetes: 6 people, 12.24%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 10.20%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.16%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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