Zofran and Riociguat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Riociguat (riociguat). Common drug interactions include erythema among females and atrial flutter among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Riociguat. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Riociguat?

Riociguat has active ingredients of riociguat. eHealthMe is studying from 2,582 Riociguat users. Check the latest studies of Riociguat.

On Jul, 07, 2026

24 people who take Zofran and Riociguat together, and have interactions are studied.

What are the common drug interactions of Zofran and Riociguat, by gender? *:

female:

Erythema (redness of the skin)
Feeling hot
Gallbladder disorder
Gallbladder pain
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Glomerular filtration rate decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hypokalaemia (low potassium)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Epistaxis (bleed from the nose)
Dyspnoea (difficult or laboured respiration)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Skin haemorrhage (bleeding into skin)
Asthenia (weakness)
Cardiac failure
Cardiac output decreased
Dizziness
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the common drug interactions of Zofran and Riociguat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Device dislocation
Diarrhoea
Dizziness
Drug intolerance (drug sensitivity)
Erythema (redness of the skin)
Feeling hot
Glomerular filtration rate decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

60+:

Dyspnoea (difficult or laboured respiration)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Syncope (loss of consciousness with an inability to maintain postural tone)
Anaemia (lack of blood)
Asthenia (weakness)
Disease progression
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Hypoxia (low oxygen in tissues)
Oedema (fluid collection in tissue)

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 50.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 41.67%
Multiple Myeloma (cancer of the plasma cells): 9 people, 37.50%
Stress And Anxiety: 2 people, 8.33%
Diarrhea: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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