Zolinza and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zolinza (vorinostat) and Zide (hydrochlorothiazide). Common drug interactions include adverse drug reaction among females and hypokalaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Zolinza and Zide. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Zolinza?

Zolinza has active ingredients of vorinostat. eHealthMe is studying from 949 Zolinza users. Check the latest studies of Zolinza.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 26, 2026

19 people who take Zolinza and Zide together, and have interactions are studied.

What are the common drug interactions of Zolinza and Zide, by gender? *:

female:

Adverse drug reaction
Alopecia (absence of hair from areas of the body)
Diarrhoea
Dizziness
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Hypokalaemia (low potassium)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Pulse absent
Electrocardiogram t wave inversion
Weight decreased
Anaemia (lack of blood)
Aortic valve incompetence

What are the common drug interactions of Zolinza and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Hypokalaemia (low potassium)
Electrocardiogram qt prolonged
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)
Pericardial effusion (fluid around the heart)
Syncope (loss of consciousness with an inability to maintain postural tone)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Pulse absent
Electrocardiogram t wave inversion

50-59:

Dizziness

60+:

Blood creatinine increased
Hypercalcaemia of malignancy (elevated calcium (ca+) level in the blood with cancer)
Drug intolerance (drug sensitivity)
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)
Hospitalisation
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 8 people, 42.11%
Pain: 6 people, 31.58%
Multiple Myeloma (cancer of the plasma cells): 4 people, 21.05%
Metastases To Lung (cancer spreads to lung): 3 people, 15.79%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 3 people, 15.79%
Sleep Disorder: 2 people, 10.53%
Stress And Anxiety: 1 person, 5.26%
Seasonal Allergy (allergic condition due to certain season): 1 person, 5.26%
Rickets (softening of bones): 1 person, 5.26%
Renal Cell Carcinoma (a kidney cancer): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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