Zolmitriptan and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zolmitriptan (zolmitriptan) and Melatonin (melatonin). Common drug interactions include weight decreased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Zolmitriptan and Melatonin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Zolmitriptan?

Zolmitriptan has active ingredients of zolmitriptan. It is often used in migraine. eHealthMe is studying from 2,568 Zolmitriptan users. Check the latest studies of Zolmitriptan.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Aug, 06, 2026

35 people who take Zolmitriptan and Melatonin together, and have interactions are studied.

Zolmitriptan and Melatonin drug interactions.

What are the common drug interactions of Zolmitriptan and Melatonin, by gender? *:

female:

Weight decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Nausea (feeling of having an urge to vomit)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug dependence
Drug ineffective
Asthenia (weakness)
Chills (felling of cold)
Headache (pain in head)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

male:

Drug ineffective
Nausea (feeling of having an urge to vomit)
Emotional distress
Headache (pain in head)
Hip arthroplasty
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multiple allergies (allergy to multiple agents)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

What are the common drug interactions of Zolmitriptan and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Abdominal discomfort
Constipation
Drug effect decreased
Erythema (redness of the skin)
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Muscle spasms (muscle contraction)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Emotional distress
Hip arthroplasty
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

50-59:

Multiple allergies (allergy to multiple agents)
Nausea (feeling of having an urge to vomit)
Stress
Asthenia (weakness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug dependence
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain
Balance disorder
Chills (felling of cold)

60+:

Abdominal pain upper
Gastric haemorrhage (bleeding stomach)
Pancreatic neuroendocrine tumour

What are the existing conditions these people have? *

Sunct Syndrome (short lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing): 10 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 11.43%
Headache (pain in head): 4 people, 11.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.57%
Hiv Infection: 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.57%
Sleep Disorder: 2 people, 5.71%
Panic Disorder: 2 people, 5.71%
Pain: 2 people, 5.71%
Blood Brain Barrier Defect (blood brain barrier defect-this bbb defect causes the bbb to break down in many pathological situations eg around brain tumours and when there is inflammation in the cns): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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