Zoloft and Briviact drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Briviact (brivaracetam). Common drug interactions include muscle spasms among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Briviact. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Briviact?

Briviact has active ingredients of brivaracetam. It is often used in epilepsy. eHealthMe is studying from 3,433 Briviact users. Check the latest studies of Briviact.

On Aug, 01, 2026

33 people who take Zoloft and Briviact together, and have interactions are studied.

What are the common drug interactions of Zoloft and Briviact, by gender? *:

female:

Muscle spasms (muscle contraction)
Cyst (a closed sac)
Post procedural complication
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sacral pain (pain at sacrum bone region)
Abnormal dreams
Affective disorder (mental disorder)

male:

Constipation
Abdominal pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Cough
Dehydration (dryness resulting from the removal of water)
Delusion of grandeur
Fatigue (feeling of tiredness)
Gait disturbance
Haemorrhage (bleeding)
Heart rate irregular

What are the common drug interactions of Zoloft and Briviact, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Aggression
Back pain
Cough
Heart rate irregular
Mood altered (changes in mood)
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Pneumonia
Respiratory tract infection
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Delusion of grandeur
Hypersexuality
Irritability
Muscle spasms (muscle contraction)
Visual impairment
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

50-59:

Abdominal pain
Blood homocysteine increased
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Fall
Gait disturbance
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 36.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 36.36%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 21.21%
Drowsiness: 3 people, 9.09%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.06%
Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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