Zoloft and Dificid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Dificid (fidaxomicin). Common drug interactions include dry skin among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Dificid. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Dificid?

Dificid has active ingredients of fidaxomicin. It is often used in clostridium difficile colitis. eHealthMe is studying from 1,295 Dificid users. Check the latest studies of Dificid.

On Jul, 27, 2026

12 people who take Zoloft and Dificid together, and have interactions are studied.

What are the common drug interactions of Zoloft and Dificid, by gender? *:

female:

Dry skin
Erythema (redness of the skin)
Lung disorder (lung disease)
Pain
Petechiae (a small red or purple spot caused by bleeding into the skin)
Rash
Rash erythematous (redness of the skin)
Skin induration (an abnormally hard spot or area on the skin)
Skin swelling
Swelling

male:

Cardiac arrest
Chronic kidney disease
Erythema (redness of the skin)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypersensitivity
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Renal failure (kidney dysfunction)
Urinary tract infection

What are the common drug interactions of Zoloft and Dificid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cardiac arrest
Chronic kidney disease
Erythema (redness of the skin)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypersensitivity
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Renal failure (kidney dysfunction)

60+:

Disease recurrence
Urinary tract infection
Skin induration (an abnormally hard spot or area on the skin)
Skin swelling
Swelling
Urticaria (rash of round, red welts on the skin that itch intensely)
Wheezing (a high-pitched whistling sound made while you breath)
Fall
Joint swelling
Local swelling (swelling at the site of some application of substance or injury)

What are the existing conditions these people have? *

Asthma: 2 people, 16.67%
High Blood Pressure: 2 people, 16.67%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 8.33%
Stress And Anxiety: 1 person, 8.33%
Clostridial Infection (infectious conditions by clostridium bacteria): 1 person, 8.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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