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Zoloft and Entacapone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Entacapone (entacapone). Common drug interactions include constipation among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Entacapone. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Entacapone?

Entacapone has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 4,261 Entacapone users. Check the latest studies of Entacapone.

On Jul, 19, 2026

51 people who take Zoloft and Entacapone together, and have interactions are studied.

Zoloft and Entacapone drug interactions.

What are the common drug interactions of Zoloft and Entacapone, by gender? *:

female:

  1. Constipation
  2. Death
  3. Dementia (madness)
  4. Drug ineffective
  5. Dry skin
  6. Dysgeusia (disorder of the sense of taste)
  7. Feeling cold
  8. Freezing phenomenon
  9. Hallucination, auditory (perceiving sounds without auditory stimulus)
  10. Heart rate increased

male:

  1. Fall
  2. Hallucination (an experience involving the perception of something not present)
  3. Drug ineffective
  4. Pneumonia
  5. Abnormal dreams
  6. Adverse drug reaction
  7. Anaemia (lack of blood)
  8. Aortic valve disease
  9. Arrhythmia (irregular heartbeat)
  10. Balance disorder

What are the common drug interactions of Zoloft and Entacapone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Dizziness
  2. Freezing phenomenon
  3. Muscle spasms (muscle contraction)
  4. Tremor (trembling or shaking movements in one or more parts of your body)

60+:

  1. Fall
  2. Gait disturbance
  3. Nephrolithiasis (calculi in the kidneys)
  4. Pneumonia
  5. Abdominal pain upper
  6. Abnormal behaviour
  7. Anaemia (lack of blood)
  8. Aortic valve disease
  9. Arrhythmia (irregular heartbeat)
  10. Benign prostatic hyperplasia (benign enlargement of the prostate)

What are the existing conditions these people have? *

  1. Hallucinations (sensations that appear real but are created by your mind): 10 people, 19.61%
  2. Delusion (a false belief or opinion): 8 people, 15.69%
  3. On And Off Phenomenon: 6 people, 11.76%
  4. Stress And Anxiety: 4 people, 7.84%
  5. Pain: 3 people, 5.88%
  6. Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and Entacapone?

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- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zoloft and Entacapone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Entacapone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zoloft and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Entacapone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride and entacapone (the active ingredients of Zoloft and Entacapone, respectively), and Zoloft and Entacapone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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