Zoloft and Epzicom drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Epzicom (abacavir sulfate; lamivudine). Common drug interactions include neoplasm malignant among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Epzicom. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Epzicom?

Epzicom has active ingredients of abacavir sulfate; lamivudine. It is often used in hiv infection. eHealthMe is studying from 4,937 Epzicom users. Check the latest studies of Epzicom.

On Jul, 18, 2026

47 people who take Zoloft and Epzicom together, and have interactions are studied.

What are the common drug interactions of Zoloft and Epzicom, by gender? *:

female:

Neoplasm malignant (cancer tumour)
Pruritus (severe itching of the skin)
Quality of life decreased
Seasonal allergy (allergic condition due to certain season)
Temperature intolerance (inability to go in temperature)
Tooth extraction
Viith nerve paralysis
Weight decreased
Gastritis (inflammation of stomach)
Suicidal behaviour

male:

Emotional distress
Pain
Osteomalacia (softening of the bones due to a lack of vitamin d)
Asthenia (weakness)
Bone loss
Cellulitis (infection under the skin)
Lower limb fracture
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Osteopenia (a condition where bone mineral density is lower than normal)

What are the common drug interactions of Zoloft and Epzicom, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Bone loss
Emotional distress
Pain
Tooth loss
Alopecia (absence of hair from areas of the body)
Drug hypersensitivity
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)

40-49:

Mobility decreased (ability to move is reduced)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Periorbital haematoma (collection of blood around the eyes)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rib fracture
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)

50-59:

Chronic kidney disease
Emotional distress
Dry eye (lack of adequate tears)
Faecaloma (hard mass of fecal matter)
Fatigue (feeling of tiredness)
Pneumonia
Proteinuria (presence of protein in the urine)
Renal failure (kidney dysfunction)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Lower limb fracture

60+:

n/a

What are the existing conditions these people have? *

Pain: 5 people, 10.64%
High Blood Pressure: 5 people, 10.64%
Anaemia (lack of blood): 4 people, 8.51%
Urinary Retention (the inability to completely or partially empty the bladder): 3 people, 6.38%
Oral Candidiasis (fungal infection of mouth): 3 people, 6.38%
Neuralgia (pain in one or more nerves): 3 people, 6.38%
High Blood Cholesterol: 3 people, 6.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.38%
Dyspnea (difficult or laboured breathing): 3 people, 6.38%
Addison's Disease (addison's disease, a hormonal disorder disease): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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