Zoloft and Parnate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Parnate (tranylcypromine sulfate). Common drug interactions include headache among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Parnate. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Parnate?

Parnate has active ingredients of tranylcypromine sulfate. It is often used in depression. eHealthMe is studying from 1,131 Parnate users. Check the latest studies of Parnate.

On Aug, 07, 2026

20 people who take Zoloft and Parnate together, and have interactions are studied.

What are the common drug interactions of Zoloft and Parnate, by gender? *:

female:

Headache (pain in head)
Homicidal ideation (thoughts about human killing another human)
Insomnia (sleeplessness)
Irritability
Libido decreased (loss of interest in sex)
Nausea (feeling of having an urge to vomit)
Suicidal ideation
Weight increased
Drug ineffective
Dry mouth

male:

Drug dependence
Headache (pain in head)
Tremor (trembling or shaking movements in one or more parts of your body)
Adjustment disorder
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chest pain
Collapse (sudden functional breakdown)
Confusion
Crying

What are the common drug interactions of Zoloft and Parnate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug dependence
Headache (pain in head)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Neck pain
Pain in limb
Rebound effect (take-back effect)
Sleep disorder
Stress symptoms
Insomnia (sleeplessness)
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Drug ineffective
Impotence (powerlessness)

40-49:

Collapse (sudden functional breakdown)
Overdose

50-59:

Dry mouth
Poor dental condition
Tooth disorder (tooth disease)
Tooth fracture

60+:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Confusional state
Hyperglycaemia (high blood sugar)
Hypersomnia (excessive daytime sleepiness (eds))
Maternal exposure during pregnancy (use of substance during pregnancy)
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Weight Loss: 1 person, 5.00%
Stress And Anxiety: 1 person, 5.00%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 5.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.00%
Completed Suicide (act of taking one's own life): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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