Zoloft and Percodan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate). Common drug interactions include anaemia among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Percodan. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

On Jul, 20, 2026

40 people who take Zoloft and Percodan together, and have interactions are studied.

What are the common drug interactions of Zoloft and Percodan, by gender? *:

female:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Bone disorder
Breath odour
Cachexia (loss of weight)
Cellulitis (infection under the skin)
Chest pain
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

male:

Headache (pain in head)
Insomnia (sleeplessness)
Gastritis (inflammation of stomach)
Alcoholism (problems with alcohol)
Arthralgia (joint pain)
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Drug screen positive
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Zoloft and Percodan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Rash
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Drug hypersensitivity
Rash erythematous (redness of the skin)
Blood albumin decreased
Blood calcium decreased
Blood urea decreased
Fatigue (feeling of tiredness)
Gallbladder disorder

20-29:

n/a

30-39:

Headache (pain in head)
Drug dependence
Emotional distress
Insomnia (sleeplessness)
Vomiting
Abdominal pain upper
Alcoholism (problems with alcohol)
Arthralgia (joint pain)
Back pain
Drug abuser

40-49:

Blood alkaline phosphatase increased
Burns second degree
Confusion
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dehydration (dryness resulting from the removal of water)
Drug effect decreased
Dry mouth
Dysgeusia (disorder of the sense of taste)
Headache (pain in head)
Influenza like illness

50-59:

Abdominal sepsis (abdominal infection)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bone disorder
Breath odour
Cachexia (loss of weight)
Cellulitis (infection under the skin)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)

60+:

Drug hypersensitivity
Anal pruritus (anal itching)
Influenza like illness
Rash erythematous (redness of the skin)

What are the existing conditions these people have? *

Hepatitis C: 3 people, 7.50%
Hiv Infection: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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