Zoloft and Prosom drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Prosom (estazolam). Common drug interactions include diabetes mellitus among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Prosom. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Prosom?

Prosom has active ingredients of estazolam. It is often used in insomnia. eHealthMe is studying from 340 Prosom users. Check the latest studies of Prosom.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

16 people who take Zoloft and Prosom together, and have interactions are studied.

What are the common drug interactions of Zoloft and Prosom, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Alopecia (absence of hair from areas of the body)
Blood glucose decreased
Cardiac disorder
Cardiac failure congestive
Constipation
Dependence
Drug addiction
Hair disorder
Hypoglycaemia (deficiency of glucose in the bloodstream)

male:

Aggression
Completed suicide (act of taking one's own life)
Dry mouth
Herpes zoster
Infection
Nausea (feeling of having an urge to vomit)
Rash
Restlessness (not able to rest)
Sedation
Tremor (trembling or shaking movements in one or more parts of your body)

What are the common drug interactions of Zoloft and Prosom, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Migraine (headache)
Thrombosis (formation of a blood clot inside a blood vessel)
Type 1 diabetes mellitus
Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)

30-39:

n/a

40-49:

Blood glucose decreased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pain in limb

50-59:

Overdose
Aggression
Completed suicide (act of taking one's own life)
Hallucination (an experience involving the perception of something not present)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Alopecia (absence of hair from areas of the body)
Hair disorder
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Personality disorder
Restlessness (not able to rest)

60+:

Drug ineffective
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Sedation
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Chromatopsia (visual defect in which colourless objects appear to be tinged with colour)
Constipation
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth
Herpes zoster

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 18.75%
Sleep Disorder: 3 people, 18.75%
Toothaches (tooth pain): 1 person, 6.25%
Post-Traumatic Stress Disorder: 1 person, 6.25%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 1 person, 6.25%
Pain: 1 person, 6.25%
Nightmares (unpleasant dreams): 1 person, 6.25%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 1 person, 6.25%
Facial Pain: 1 person, 6.25%
Asthma: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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