Zoloft and Rifampin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Rifampin (rifampin). Common drug interactions include skin induration among females and immune system disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Rifampin. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Rifampin?

Rifampin has active ingredients of rifampin. It is often used in tuberculosis. eHealthMe is studying from 12,339 Rifampin users. Check the latest studies of Rifampin.

On Jul, 10, 2026

62 people who take Zoloft and Rifampin together, and have interactions are studied.

What are the common drug interactions of Zoloft and Rifampin, by gender? *:

female:

Skin induration (an abnormally hard spot or area on the skin)
Urinary tract infection bacterial
Vasculitis (inflammation of a blood vessel or blood vessels)
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Arthropathy
Aspartate aminotransferase increased
Ataxia (loss of full control of bodily movements)
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)

male:

Immune system disorder
Chronic kidney disease
Diabetic complication
Impaired work ability
Staphylococcal infection (an infection with staphylococcus bacteria)
Abdominal pain
Back pain
Blood glucose increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Splenomegaly (enlargement of spleen)

What are the common drug interactions of Zoloft and Rifampin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood glucose increased

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Feeling hot
Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Chest pain
Clamminess (moist, sticky, and cold to the touch)

40-49:

Haemoglobin increased
Hyperlipidaemia (presence of excess lipids in the blood)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mitral valve incompetence (inefficient heart valve)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nasopharyngitis (inflammation of the nasopharynx)
Neck pain
Obesity (having too much body fat)

50-59:

Hypersensitivity
Burning sensation
Chest pain
Chills (felling of cold)
Chronic kidney disease
Coagulopathy (blood's ability to clot is impaired)
Diarrhoea
Disturbance in attention
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

60+:

International normalised ratio increased
Dyspnoea (difficult or laboured respiration)
Blood glucose increased
Cardiac arrest
Drug dependence
Drug effect decreased
Drug ineffective
Epistaxis (bleed from the nose)
Heart rate increased
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Ankylosing Spondylitis (type of arthritis affecting the spine): 10 people, 16.13%
Pain: 8 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 11.29%
Fever: 7 people, 11.29%
High Blood Pressure: 6 people, 9.68%
Sleep Disorder: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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