Zoloft and Sofosbuvir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Sofosbuvir (sofosbuvir). Common drug interactions include anaemia among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Sofosbuvir. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

On Jul, 13, 2026

32 people who take Zoloft and Sofosbuvir together, and have interactions are studied.

Zoloft and Sofosbuvir drug interactions.

What are the common drug interactions of Zoloft and Sofosbuvir, by gender? *:

female:

Anaemia (lack of blood)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Choking sensation (feeling of obstruction in respiratory system)
Cough
Death
Drug ineffective
Hepatitis c
Increased upper airway secretion
Somnolence (a state of near-sleep, a strong desire for sleep)
Bacteraemia (presence of bacteria in the blood)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fall
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Injury
Insomnia (sleeplessness)
Pain in extremity
Pneumonia
Vision blurred

What are the common drug interactions of Zoloft and Sofosbuvir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pain
Pain in extremity
Pruritus (severe itching of the skin)
Rash
Suicidal ideation

30-39:

Death
Asthenia (weakness)
Back pain
Chest pain
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Groin pain
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Klebsiella sepsis (klebsiella causes a potentially fatal whole-body inflammation)

40-49:

Pneumonia
Anaemia (lack of blood)
Castleman's disease (a disease of lymph nodes and related tissues)
Cellulitis (infection under the skin)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Increased appetite
Insomnia (sleeplessness)
Irritability
Photosensitivity reaction
Presyncope

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fall
Head injury
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Brain contusion (a form of traumatic brain injury)
Cerebral haemorrhage (bleeding within the brain)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Choking sensation (feeling of obstruction in respiratory system)
Cough

60+:

Anaemia (lack of blood)
Bacteraemia (presence of bacteria in the blood)
Pulmonary toxicity (side effects on the lungs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Urinary tract infection
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Blood glucose increased
Drug ineffective
Erysipelas (bacterial skin infection)
Fall

What are the existing conditions these people have? *

Hepatitis C: 21 people, 65.62%
Stress And Anxiety: 3 people, 9.38%
Pain: 3 people, 9.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.38%
Diabetes: 3 people, 9.38%
Sleep Disorder: 2 people, 6.25%
Oedema (fluid collection in tissue): 2 people, 6.25%
Neuropathy Peripheral (surface nerve damage): 2 people, 6.25%
Insomnia (sleeplessness): 2 people, 6.25%
Hypokalemia (low potassium): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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