Zoloft and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include insomnia among females and osteomyelitis among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Solu-cortef. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

On Aug, 12, 2026

74 people who take Zoloft and Solu-cortef together, and have interactions are studied.

Zoloft and Solu-cortef drug interactions.

What are the common drug interactions of Zoloft and Solu-Cortef, by gender? *:

female:

Insomnia (sleeplessness)
Pruritus allergic (severe allergic itching of the skin)
Pulmonary embolism (blockage of the main artery of the lung)
Small intestinal obstruction (blockage in small intestine)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Venous injury
Abdominal pain
Diarrhoea
Eating disorder
Flushing (the warm, red condition of human skin)

male:

Osteomyelitis (infection of bone)
Anaemia (lack of blood)
Rotator cuff repair
Ulcerative keratitis (ulcerative inflammation of the cornea)
Vomiting
Aggression
Arrhythmia (irregular heartbeat)
Back pain
Bone mass decreased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

What are the common drug interactions of Zoloft and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood bilirubin increased
Decreased appetite
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)

20-29:

General physical health deterioration (weak health status)
Infusion related reaction
Abdominal pain
Abdominal pain lower
Blood pressure decreased
Chest discomfort
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Eating disorder
Fatigue (feeling of tiredness)

30-39:

Abdominal pain
Confusional state
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Skin wound
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

40-49:

Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Loss of consciousness
Malignant melanoma of skin stage unspecified (cancer of skin un specific stage)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myopathy steroid (a muscular disease in which the muscle fibres do not function due to steroid)
Oropharyngeal pain
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Purulent discharge (discharge that contains pus)

50-59:

Nausea (feeling of having an urge to vomit)
Chills (felling of cold)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Pyrexia (fever)
Vomiting
Abdominal pain
Adverse event
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)

60+:

Cough
Dyspnoea (difficult or laboured respiration)
Urticaria (rash of round, red welts on the skin that itch intensely)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Haematemesis (vomiting of blood)
Mallory-weiss syndrome (gastro-oesophageal laceration syndrome refers to bleeding from tears)
Nasopharyngitis (inflammation of the nasopharynx)
Vomiting
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain

What are the existing conditions these people have? *

Stress And Anxiety: 12 people, 16.22%
Nausea (feeling of having an urge to vomit): 10 people, 13.51%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 13.51%
Lipidosis (disorder of lipid metabolism involving abnormal accumulation of lipids in the reticuloendothelial cells): 6 people, 8.11%
Immune System Disorder: 6 people, 8.11%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 6 people, 8.11%
Skin Blushing/flushing (a sudden reddening of the face, neck): 5 people, 6.76%
Migraine (headache): 5 people, 6.76%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 5.41%
Pain: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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