Zoloft and Tremfya drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Tremfya (guselkumab). Common drug interactions include injection site mass among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Tremfya. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Tremfya?

Tremfya has active ingredients of guselkumab. eHealthMe is studying from 22,557 Tremfya users. Check the latest studies of Tremfya.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

31 people who take Zoloft and Tremfya together, and have interactions are studied.

What are the common drug interactions of Zoloft and Tremfya, by gender? *:

female:

Injection site mass
Injection site reaction
Rash
Colon cancer
Decreased appetite
Drug exposure before pregnancy
Fungal infection
Impetigo (contagious skin infection)
Onychomycosis (fungal infection of the nail)
Oral herpes (viral infection of mouth)

male:

Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Fatigue (feeling of tiredness)
Hospitalisation
Mood swings (an extreme or rapid change in mood)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Therapeutic response decreased (less preventive response)

What are the common drug interactions of Zoloft and Tremfya, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injection site erythema (redness at injection site)
Injection site pain
Injection site reaction

30-39:

Injection site reaction

40-49:

Injection site mass
Decreased appetite
Fungal infection
Impetigo (contagious skin infection)
Onychomycosis (fungal infection of the nail)
Oral herpes (viral infection of mouth)
Blood bilirubin increased
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site swelling

50-59:

Arthralgia (joint pain)
Asthma
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Psoriasis (immune-mediated disease that affects the skin)
Rash
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Alopecia (absence of hair from areas of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Psoriasis (immune-mediated disease that affects the skin)
Thyroid disorder (thyroid diseases)
Urinary tract infection
Weight decreased
Back disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diarrhoea
Hospitalisation

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 23 people, 74.19%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 8 people, 25.81%
Stress And Anxiety: 7 people, 22.58%
Acne (skin problems that cause pimples): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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