Zoloft and Zicam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Zicam (zinc gluconate). Common drug interactions include anosmia among females and anosmia among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Zicam. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Zicam?

Zicam has active ingredients of zinc gluconate. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 5,298 Zicam users. Check the latest studies of Zicam.

On Jul, 26, 2026

12 people who take Zoloft and Zicam together, and have interactions are studied.

What are the common drug interactions of Zoloft and Zicam, by gender? *:

female:

Anosmia (partial or complete loss of the sense of smell)
Dysplasia (enlargement of an organ or tissue)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gastrointestinal malformation
Haematochezia (passage of stools containing blood)
Hypokinesia (decreased bodily movement)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lung disorder (lung disease)
Mitral valve incompetence (inefficient heart valve)

male:

Anosmia (partial or complete loss of the sense of smell)

What are the common drug interactions of Zoloft and Zicam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Dysgeusia (disorder of the sense of taste)
Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances))

50-59:

Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Glossitis (infection of tongue with soreness)

60+:

Anosmia (partial or complete loss of the sense of smell)
Aortic dilatation
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Gastrointestinal malformation
Haematochezia (passage of stools containing blood)
Hypokinesia (decreased bodily movement)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lung disorder (lung disease)
Mitral valve incompetence (inefficient heart valve)
Otitis media (inflammation of the middle ear)

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 2 people, 16.67%
Postpartum Depression (depression suffered by a mother following childbirth): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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