Zolpidem and Hydrocortisone sodium succinate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zolpidem (zolpidem tartrate) and Hydrocortisone sodium succinate (hydrocortisone sodium succinate). Common drug interactions include pyrexia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Zolpidem and Hydrocortisone sodium succinate. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.

What is Hydrocortisone sodium succinate?

Hydrocortisone sodium succinate has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 3,777 Hydrocortisone sodium succinate users. Check the latest studies of Hydrocortisone sodium succinate.

eHealthMe: drug outcomes in the real world

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On Aug, 20, 2026

92 people who take Zolpidem and Hydrocortisone sodium succinate together, and have interactions are studied.

Zolpidem and Hydrocortisone sodium succinate drug interactions.

What are the common drug interactions of Zolpidem and Hydrocortisone Sodium Succinate, by gender? *:

female:

Pyrexia (fever)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Headache (pain in head)
Oral disorder (mouth disease)
Hyperglycaemia (high blood sugar)
Liver disorder (liver diseases)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
Venoocclusive liver disease (small veins in the liver are obstructed)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)

male:

Pyrexia (fever)
Nausea (feeling of having an urge to vomit)
Diarrhoea
Hypokalaemia (low potassium)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Anaemia (lack of blood)
Body temperature increased
Cellulitis (infection under the skin)
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)

What are the common drug interactions of Zolpidem and Hydrocortisone Sodium Succinate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infection
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Renal failure acute (rapid kidney dysfunction)
Transplant rejection (a transplant material is not worked)

20-29:

Liver disorder (liver diseases)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Hepatic failure (liver failure)
Septic shock (shock due to blood infection)
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Altered state of consciousness (altered state of mind)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Blood lactate dehydrogenase increased
Cardiac tamponade (fluid accumulates in heart covering)

30-39:

Pyrexia (fever)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Headache (pain in head)
Neuropathy peripheral (surface nerve damage)
Oral disorder (mouth disease)
Pruritus (severe itching of the skin)
Oedema (fluid collection in tissue)
Toothache (tooth pain)
Diarrhoea

40-49:

Blood bilirubin increased
Weight increased
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abnormal behaviour
Acute graft versus host disease in liver (acute complication in liver following an allogeneic tissue/blood transplant)
Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Antithrombin iii decreased
Cytomegalovirus test positive
Disease recurrence

50-59:

Constipation
Cough
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Infection
Pyrexia (fever)
Rash
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

60+:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Thrombocytopenia (decrease of platelets in blood)
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Vomiting
Dyspnoea (difficult or laboured respiration)
Dementia (madness)

What are the existing conditions these people have? *

High Blood Pressure: 24 people, 26.09%
Constipation: 20 people, 21.74%
Fever: 17 people, 18.48%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 16 people, 17.39%
Bone Marrow Conditioning Regimen: 12 people, 13.04%
Hypokalemia (low potassium): 12 people, 13.04%
Aplastic Anemia: 10 people, 10.87%
Multiple Myeloma (cancer of the plasma cells): 10 people, 10.87%
Infection: 10 people, 10.87%
Diarrhea: 9 people, 9.78%

* Approximation only. Some reports may have incomplete information.

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