Zolpidem and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zolpidem (zolpidem tartrate) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include dehydration among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zolpidem and Ziac. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

On Jul, 26, 2026

40 people who take Zolpidem and Ziac together, and have interactions are studied.

What are the common drug interactions of Zolpidem and Ziac, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Respiratory distress (difficulty in breathing)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Nausea (feeling of having an urge to vomit)
Pain
Physical disability
Adverse event
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Chronic kidney disease
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Arthralgia (joint pain)
Blood glucose fluctuation
Cough
Dry mouth
Dry throat
Feeling cold
Pancreatitis (inflammation of pancreas)
Therapeutic response unexpected

What are the common drug interactions of Zolpidem and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)

50-59:

Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Respiratory distress (difficulty in breathing)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Physical disability
Adverse event
Fatigue (feeling of tiredness)
Performance status decreased
Weight decreased

60+:

Nausea (feeling of having an urge to vomit)
Pain
Distractibility (inability to sustain one's attention)
Drug administration error
Feeling cold
Headache (pain in head)
Memory impairment
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Therapeutic response unexpected

What are the existing conditions these people have? *

Sleep Disorder: 18 people, 45.00%
Depression: 14 people, 35.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 32.50%
Nausea (feeling of having an urge to vomit): 13 people, 32.50%
Muscle Spasms (muscle contraction): 13 people, 32.50%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 13 people, 32.50%
Pain: 7 people, 17.50%
Small Cell Lung Cancer Stage Unspecified (lung cancer in unknown stage): 5 people, 12.50%
Sciatic Nerve Injury: 5 people, 12.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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