Zometa and Piqray drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zometa (zoledronic acid) and Piqray (alpelisib). Common drug interactions include metastases to bone among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Zometa and Piqray. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

What is Piqray?

Piqray has active ingredients of alpelisib. eHealthMe is studying from 7,290 Piqray users. Check the latest studies of Piqray.

On Jul, 09, 2026

57 people who take Zometa and Piqray together, and have interactions are studied.

What are the common drug interactions of Zometa and Piqray, by gender? *:

female:

Metastases to bone (cancer spreads to bone)
Vomiting
Drug ineffective
Gait disturbance
Abdominal discomfort
Flatulence (flatus expelled through the anus)
Insomnia (sleeplessness)
Weight increased
Liver injury
Blood glucose increased

male:

Confusional state
Hyperglycaemia (high blood sugar)

What are the common drug interactions of Zometa and Piqray, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Confusional state
Hyperglycaemia (high blood sugar)

40-49:

Osteonecrosis of jaw (death of bone of jaw)
Abdominal pain
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Back pain
Blood glucose increased
Decreased appetite
Dry skin
Fatigue (feeling of tiredness)
Haemoglobin decreased
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Weight decreased
Blood glucose increased
Decreased appetite
Liver injury
Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Abdominal pain upper
Hyperglycaemia (high blood sugar)

60+:

Rash
Cataract (clouding of the lens inside the eye)
Pyrexia (fever)
Skin reaction
Stomatitis (inflammation of mucous membrane of mouth)
Tooth infection
Death
Disease progression
Dyspnoea (difficult or laboured respiration)
Hyperglycaemia (high blood sugar)

What are the existing conditions these people have? *

Breast Cancer: 28 people, 49.12%
Breast Cancer Metastatic: 9 people, 15.79%
Metastases To Bone (cancer spreads to bone): 8 people, 14.04%
Breast Cancer Female: 8 people, 14.04%
Sinusitis (inflammation of sinus): 3 people, 5.26%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 3 people, 5.26%
Pericardial Effusion (fluid around the heart): 3 people, 5.26%
Bone Cancer Metastatic: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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