Zonegran and Afinitor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Afinitor (everolimus). Common drug interactions include dysmenorrhoea among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Afinitor. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

69 people who take Zonegran and Afinitor together, and have interactions are studied.

Zonegran and Afinitor drug interactions.

What are the common drug interactions of Zonegran and Afinitor, by gender? *:

female:

Dysmenorrhoea (painful menstruation)
Menstruation irregular
Mouth ulceration (mouth ulcers)
Neoplasm progression (growth of tumour)
Aphthous ulcer (mouth ulcer)
Headache (pain in head)
Therapeutic response decreased (less preventive response)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abnormal behaviour
Acne (skin problems that cause pimples)

male:

Cough
Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Blood triglycerides increased
Ocular neoplasm (eye tumour)
Complex partial seizures (epileptic seizure)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Loss of consciousness
Rash
Herpes zoster

What are the common drug interactions of Zonegran and Afinitor, by age (0-1 to 60+)? *:

0-1:

Coma (state of unconsciousness lasting more than six hours)
Complex partial seizures (epileptic seizure)
Cough
Diarrhoea
Ear infection
Electrolyte imbalance
Infantile spasms
Rhinorrhoea (watery mucus discharge from the nose)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting

2-9:

Drug level increased
Viral infection
Cough
Decreased appetite
Diarrhoea
Eye disorder
Infantile spasms
Influenza
Influenza like illness
Irritability

10-19:

Blood cholesterol increased
Neoplasm progression (growth of tumour)
Abnormal behaviour
Pyrexia (fever)
Staphylococcal infection (an infection with staphylococcus bacteria)
Blood triglycerides increased
Vomiting
Blood pressure increased
Drug level increased
Astrocytoma, low grade (low grade tumour of the brain that originate in a particular kind of glial-cells)

20-29:

Oliguria (not enough urine)
Oropharyngeal pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Eye infection
Fall
Foot fracture
Oral pain
Peripheral swelling
Stomatitis (inflammation of mucous membrane of mouth)
Drug level below therapeutic

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Herpes zoster
Rash
Drug level decreased
Apnoeic attack
Joint injury
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Angiofibroma (small, reddish brown or even flesh-coloured, smooth, shiny, 0.1- to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks)
Decreased appetite
Diarrhoea

40-49:

n/a

50-59:

Blood cholesterol increased
Chills (felling of cold)
Cough
Dysmenorrhoea (painful menstruation)
Haematuria (presence of blood in urine)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Menstrual disorder (disease of menstrual cycle)
Menstruation irregular
Nasopharyngitis (inflammation of the nasopharynx)
Neoplasm progression (growth of tumour)

60+:

Blood triglycerides increased
Coma (state of unconsciousness lasting more than six hours)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Complex partial seizures (epileptic seizure)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Heart rate increased
Infection
International normalised ratio increased
Loss of consciousness

What are the existing conditions these people have? *

Angiomyolipoma (most common benign tumour of the kidney): 21 people, 30.43%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 16 people, 23.19%
Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 11 people, 15.94%
Brain Neoplasm Benign (non-cancerous tumour of brain): 8 people, 11.59%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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