Zonegran and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Aleve (naproxen sodium). Common drug interactions include drug hypersensitivity among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Aleve. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

33 people who take Zonegran and Aleve together, and have interactions are studied.

What are the common drug interactions of Zonegran and Aleve, by gender? *:

female:

Drug hypersensitivity
Weight decreased
Abnormal behaviour
Acne (skin problems that cause pimples)
Agitation (state of anxiety or nervous excitement)
Anxiety
Ear injury
Fatigue (feeling of tiredness)
Limb injury
Nausea (feeling of having an urge to vomit)

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Blast crisis in myelogenous leukaemia
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Epistaxis (bleed from the nose)
Loss of consciousness
Pneumonia
Procedural pain
Sleep disorder

What are the common drug interactions of Zonegran and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Insomnia (sleeplessness)
Abnormal behaviour
Aggression
Agitation (state of anxiety or nervous excitement)
Crying
Depression
Dizziness
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Impaired gastric emptying

30-39:

n/a

40-49:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Weight decreased
Activities of daily living impaired
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Asthenia (weakness)
Blast crisis in myelogenous leukaemia
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

50-59:

Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Bone disorder
Bone loss
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Diarrhoea

60+:

Thrombosis (formation of a blood clot inside a blood vessel)
Upper limb fracture
Depression
Disinhibition (loss of inhibition)
Emotional disorder
Emotional distress
Injury
Memory impairment
Muscular weakness (muscle weakness)
Speech disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 42.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 30.30%
Migraine (headache): 4 people, 12.12%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.06%
Headache (pain in head): 2 people, 6.06%
Drowsiness: 2 people, 6.06%
Birth Control: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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