Zonegran and Clonidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Clonidine (clonidine). Common drug interactions include adrenal insufficiency among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Clonidine. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

On Jul, 15, 2026

61 people who take Zonegran and Clonidine together, and have interactions are studied.

Zonegran and Clonidine drug interactions.

What are the common drug interactions of Zonegran and Clonidine, by gender? *:

female:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Adverse drug reaction
Aggression
Agitation (state of anxiety or nervous excitement)
Albumin globulin ratio increased
Allergy to vaccine
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anaemia (lack of blood)
Anxiety disorder
Appendicitis (inflammation of the appendix)

male:

Headache (pain in head)
Aggression
Confusional state
Fall
Neoplasm progression (growth of tumour)
Agitation (state of anxiety or nervous excitement)
Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts)
Disturbance in attention
Dry mouth
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Zonegran and Clonidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abasia (inability to walk)
Complex partial seizures (epileptic seizure)
Ear infection
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Head lag (weak head and neck control)
Muscular weakness (muscle weakness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Speech disorder
Urinary incontinence (inability to control the flow of urine and involuntary urination)

10-19:

International normalised ratio increased
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Neoplasm (tumour)
Renal impairment (severely reduced kidney function)
Respiratory rate increased (excess breathing rate/min)
Thrombocytopenia (decrease of platelets in blood)
Weight increased
Wound

20-29:

Aggression
Agitation (state of anxiety or nervous excitement)

30-39:

Dyspnoea (difficult or laboured respiration)
Eye pain
Abdominal pain upper
Alcohol poisoning
Back injury
Cervical vertebral fracture
Concussion (short loss of normal brain function in response to a head injury)
Confusional state
Drug specific antibody present
Fall

40-49:

Depression
Aggression
Anger
Headache (pain in head)
Nightmare (unpleasant dream)
Suicide attempt
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Neuropathy peripheral (surface nerve damage)
Pain

50-59:

Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Confusional state
Disturbance in attention
Dry mouth
Dysgeusia (disorder of the sense of taste)
Irritability
Memory impairment
Pruritus (severe itching of the skin)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Gingival swelling (gums swelling)
Peripheral swelling
Blood glucose increased
Confusion
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Heart rate irregular
Pancreatitis (inflammation of pancreas)
Pyrexia (fever)
Renal disorder (kidney disease)

What are the existing conditions these people have? *

Pain: 7 people, 11.48%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 9.84%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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