Zonegran and Fioricet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Fioricet (acetaminophen; butalbital; caffeine). Common drug interactions include white blood cell count increased among females and hypoaesthesia among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Fioricet. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

40 people who take Zonegran and Fioricet together, and have interactions are studied.

Zonegran and Fioricet drug interactions.

What are the common drug interactions of Zonegran and Fioricet, by gender? *:

female:

White blood cell count increased
Abdominal discomfort
Abnormal dreams
Activities of daily living impaired
Angioedema (rapid swelling of the dermis)
Application site scar
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Back injury

male:

Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Diplopia (double vision)
Disability
Epicondylitis (tennis elbow)
Essential hypertension (primary hypertension)
Essential tremor
Facial paresis (weakness in facial muscle movement)

What are the common drug interactions of Zonegran and Fioricet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Weight increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Road traffic accident
Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)
Back injury
Chest discomfort
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

40-49:

Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Swelling
Upper respiratory tract infection
Application site erythema (redness of the skin at application site)
Application site rash
Fungal infection
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Vulvovaginal pruritus (vulvovaginal severe itching)
Abnormal dreams

50-59:

Altered state of consciousness (altered state of mind)
Blood glucose increased
Chills (felling of cold)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Drug ineffective
Fall
Fear
Feeling hot

60+:

Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Muscle spasms (muscle contraction)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Blood glucose decreased
Cardiomyopathy (weakening of the heart muscle)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 22.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 20.00%
Pain: 6 people, 15.00%
High Blood Cholesterol: 5 people, 12.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 12.50%
Stress And Anxiety: 4 people, 10.00%
Sleep Disorder: 4 people, 10.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 10.00%
Breakthrough Pain: 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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