Zonegran and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Pepcid (famotidine). Common drug interactions include anaemia among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Pepcid. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 24, 2026

48 people who take Zonegran and Pepcid together, and have interactions are studied.

What are the common drug interactions of Zonegran and Pepcid, by gender? *:

female:

Anaemia (lack of blood)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Blood bicarbonate decreased
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Constipation
Cough

male:

Depression
Acute stress disorder
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Disturbance in attention
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Headache (pain in head)

What are the common drug interactions of Zonegran and Pepcid, by age (0-1 to 60+)? *:

0-1:

Cardiac arrest
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Eye movement disorder
Haematochezia (passage of stools containing blood)
Hemiparesis (weakness on one side of the body)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle spasms (muscle contraction)
Seizure cluster (small group of seizure)
Sepsis (a severe blood infection that can lead to organ failure and death)

2-9:

Neutropenia (an abnormally low number of neutrophils)

10-19:

Hypersomnia (excessive daytime sleepiness (eds))
Abdominal discomfort
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Diarrhoea
Eye irritation
Eye pain
Headache (pain in head)
Blindness unilateral
Ear infection

20-29:

Bipolar disorder (mood disorder)
Cardiac failure congestive
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Irritability
Joint injury
Mood swings (an extreme or rapid change in mood)

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Acidosis (build-up of carbon dioxide in the blood)
Acute hepatic failure
Anaemia (lack of blood)
Bedridden
Blood bicarbonate decreased
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Extremity necrosis (death of body tissue of arms and legs)
Hyperglycaemia (high blood sugar)

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Depression
Drug ineffective
Headache (pain in head)
Chronic kidney disease
Renal failure (kidney dysfunction)
Acute stress disorder
Adjustment disorder
Anxiety

50-59:

Asthenia (weakness)
Cellulitis (infection under the skin)
Eye irritation
Eye pain
Gait disturbance
Headache (pain in head)
Infusion related reaction
Myalgia (muscle pain)
Pain in extremity
Pneumonia

60+:

Penile pain
Abdominal pain
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Osteoporosis (bones weak and more likely to break)
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)
Right ventricular failure (right half of the heart fails to work)
Septic encephalopathy (disorder or disease of the brain due to blood infection with bacteria)
Typhoid fever
Urinary tract infection

What are the existing conditions these people have? *

Pain: 11 people, 22.92%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 16.67%
Stress And Anxiety: 6 people, 12.50%
Nausea (feeling of having an urge to vomit): 6 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 12.50%
Hypersensitivity: 5 people, 10.42%
Migraine (headache): 5 people, 10.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 10.42%
Nausea And Vomiting: 4 people, 8.33%
Optic Neuritis (optic nerve inflammation): 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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